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The fresh leaves extract of Carpobrotus edulis improved the angiogenesis condition in cut wound tissue of rats
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Zahra Changizi   , Elham Safarpour kapurchal , Azam Moslehi , Mohsen Eslami Farsani |
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Abstract: (279 Views) |
Introduction: Carpobrotus edulis is a plant native to South Africa that has long been used in wound healing. The main effects of C.edulis are anti-oxidant, anti-fungal, anti-microbial, anti-viral, and anti-inflammatory. The present study examines the angiogenic effects of C.edulis in the process of cut wound healing.
Methods and Materials: 30 adult rats were anesthetized, had their backs shaved, and a cut wound was made. The wounds were topically treated for 21 days (periods: 7, 14, and 21) following the induced incision. The treatments were prescribed every day: Control (without any treatment), Sham (distilled water; 2 ml), and Treatment (crude extracts; 2 ml). After 21 days, the rats were anesthetized and their tissues were collected for histological analysis. The angiogenic effects of C.edulis fresh leaf extract in the wound-healing process of mice were investigated through hematoxylin and eosin (H&E) staining in experimental groups.
Results: In the initial stages, a high number of blood vessels were seen, but they gradually subsided with increasing recovery. In the overall evaluation at the end of the experiment, it was found that the treatment group showed a significant decrease in total blood vessels compared to the control and sham groups (p<0.001).
Conclusion: Briefly, our findings showed that the fresh leaf extract of C.edulis improved angiogenesis in the cut wound tissue of rats.
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| Keywords: Carpobrotus edulis, incision wound, angiogenesis, leaves extract |
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Full-Text [PDF 258 kb]
(38 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/10 | Accepted: 2023/08/23 | Published: 2023/08/23
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