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Effect of fenofibrate on plasma level of BDNF and brain oxidative stress markers in pentylenetetrazole-induced kindling seizure in mice
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Nahid Sarahian    , Mohammad Taghi Mohammadi , Shima Shahyad , Mohsen Rezaei |
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Abstract: (1750 Views) |
| Introduction: The neuroprotective effect and pleiotropic functions of PPARα agonists (peroxisome proliferator activated receptor-alpha) such as fenofibrate and bezafibrate have been demonstrated by the previous studies. The current study evaluated the antiepileptic effects and neuroprotective functions of fenofibrate in pentylenetetrazole (PTZ)-induced kindling seizure in mice.
Materials and Methods: Adult male NMRI mice were randomly assigned into three groups (n=8): Control, untreated kindled mice and fenofibrate-treated kindled animals. Repeated intraperitoneal injections of PTZ (45 mg/kg) once every 48 hours were used to develop the kindling seizure for 21 days. Treated mice were administered orally fenofibrate at doses of 30 mg/kg/day. Plasma level of brain-derived neurotrophic factor (BDNF), brain level of malondialdehyde (MDA) and histopathological changes were evaluated at termination of the study.
Results: Fenofibrate administration considerably improved the seizure latency in treated kindled mice. Fenofibrate significantly (P |
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| Keywords: Fenofibrate, Status epilepticus, Neuroprotection, Brain-Derived Neurotrophic Factor, Malondialdehyde |
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Full-Text [PDF 1437 kb]
(378 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2021/01/16 | Accepted: 2021/04/21 | Published: 2021/09/28
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