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Maternal aerobic running during mid or late gestation improves the gliosis of the dentate gyrus in neonatal rat
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Behpour Yousefi   , Ali Rashidy‑Pour |
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Abstract: (188 Views) |
Introduction: Previous studies have demonstrated that several factors including physical activities enhance proliferation of progenitor of gliosis in hippocampus gyrus. In the present study, we evaluate the effects of maternal voluntary running during second, third week of the gestation on the gliosis of the dentate gyrus in neonatal rats.
Methods and Materials: In this experimental study, Wistar pregnant female rats (no=15) randomly were divided into two groups, voluntary running and control groups. Voluntary running group was divided into two subgroups (second and third week). Pregnant rats in the second week of voluntary running group and control groups during the 8th–15th days of pregnancy and pregnant rats in the third week of voluntary running group from the 15th day of pregnancy until delivery were subcutaneously injected with 100mg/kg of 5-bromo-2-deoxyuridine (BrdU) once a day at 6 pm. After birth, the rat pups' brains were removed and fixed. For histology and immunohistochemistry staining, coronal sections 40µm thick were made. Statistical analysis was performed using one-way followed by t-test. The data are presented as the mean±SEM. The differences were considered significant at p≤0.05.
Results: The mean number of astrocytes of granular layer of the dentate gyrus for the rat pups of second week voluntary running, third week voluntary running and control groups were: 127.7; 115.2 and 94 per field, respectively. The mean number of astrocytes increases 29% in the voluntary running pups compared to control group. There was a significant difference between the groups in this regard.
Conclusion: We concluded that maternal voluntary running during second, third week of the gestation may have enhanced gliosis of the dentate gyrus in neonatal rats. The proliferative and differentiation effect of voluntary running on dentate gyrus is more during second week. |
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| Keywords: Exercise, Voluntary running, Dentate gyrus, Astrocytes, Embryo |
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Full-Text [PDF 427 kb]
(25 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/03/4 | Accepted: 2023/08/10 | Published: 2023/08/10
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