Introduction:Sleep is a vital process for maintaining homeostasis and quality of human life. Sleep affects the immune system. This effect occurs through the regulation of immunological markers and their cells. The Covid-19 pandemic not only changed the lifestyle of a large part of the population, but also affected the quality of their sleep. In this article, the relationship between sleep and the immune system during the covid-19 pandemic is discussed. Search Method: This article summary has been prepared by studying published articles in this field. Results: Sleep disorders have a strong influence on the risk of infectious diseases. In the evaluation of sleep-deprived people, there is an increase in the activity of cytokines such as interferon (IFN), tumor necrosis factor (TNF- α) and interleukin 1β (IL-1β), in addition to an increase of inflammatory markers such as C-reactive protein (CRP). These results emphasize that the reduction in the quality of sleep negatively affects on the functioning of the immune system. Since sleep plays a unique role in the maintaining immunity, in situations such as Covid-19 pandemic, which naturally promote an increase in anxiety and stress, sleep can be affected and thus contribute to the deregulation of inflammatory and antiviral responses. Conclusion: Sleep exercises have a direct effect on the immunity maintenance and response. The change of circadian rhythms caused by the Covid-19 pandemic compromise the quality of sleep and consequently the immune system.