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The effect of melatonin on oxidative stress indicators in patients with beta thalassemia major in BooAli Hospital, Sari city
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Ramin Ataie   , Amirhossein Sarkhosh |
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Abstract: (211 Views) |
Introduction: One of the problems of thalassemia patients is oxidative stress caused by iron overload in these people, followed by oxidative damage to various body tissues and organs. For this reason, we investigated the effect of melatonin on oxidative stress indicators including glutathione, catalase enzyme activity and malondialdehyde level.
Methods and Materials: In this study, 24 beta-thalassemia major volunteers over 18 years of age who had sleep problems were randomly assigned to receive medication (6 mg of melatonin per day) and placebo (each for 45 days) and after receiving each and before starting In the study, serum samples were taken from patients. Some patients received medicine first and some received placebo first. At the end, three serum samples were available from each patient, and the levels of glutathione, malondialdehyde and catalase activity were measured and analyzed.
Results: Melatonin increased the level of glutathione (Hedges’ g=0.32) and decreased malondialdehyde (Hedges’ g=-5.6), but it did not have much effect on catalase enzyme activity.
Conclusion: This study shows that adding melatonin to the medication regimen of people with beta-thalassemia major can be useful in reducing oxidative stress in these patients.
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| Keywords: Melatonin, Oxidative stress, Beta thalassemia |
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Full-Text [PDF 312 kb]
(34 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/27 | Accepted: 2023/08/10 | Published: 2023/08/10
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