|
Investigation of the therapeutic effect of nicotine and its metabolites on the brain
|
Amin Ataie   |
|
|
|
Abstract: (226 Views) |
Introduction: Nicotine is a liquid alkaloid from tobacco plant. It is well known that nicotine is an agonist on nicotinic acetylcholine receptors (nAChR) in the brain. On the other hand, nicotine acts on two subunits (nAChRα9 and nAChRα10) as a receptor antagonist. Nicotine is abused commonly as an addictive drug and shows drug-reinforcement, and relapse following abstinence. Also, nicotine shows tolerance, sensitization, and physical and physiological dependency. Nicotine has some unpleasant withdrawal symptoms such as mood disorders, anxiety, irritability, difficulty concentrating, and insomnia. Nicotine has a low therapeutic index and is mild analgesic and sedative. The effect of Cotinine, active metabolite of nicotine, on Aβ1-42 neurotoxicity was investigated. Cotinine possesses a longer plasma half-life, lower toxicity and it is a partial agonist of the nicotinic acetylcholine receptors (nAChR).
Conclusion: Some in vitro and in vivo studies indicate that Cotinine prolongs the survival of cortical neurons exposed to Aβ1-42. These results indicate that cotinine has a neuroprotective effect by inhibition of the formation of amyloid beta in the brain. |
|
| Keywords: Cotinine, Nicotine, Beta-Amyloid, Neuroprotection |
|
|
Full-Text [PDF 305 kb]
(36 Downloads)
|
Type of Study: Research |
Subject:
General
Received: 2024/02/26 | Accepted: 2023/08/10 | Published: 2023/08/10
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
