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Comparative Study of Disturbance in the Peripheral Thyroid Hormone Homeostasis in the Hemodialysis Patients with End Stage Renal Disease (ESRD) in Diabetic and Non-diabetic Subjects
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Abolfazl Fateh   , Enayat Anvari |
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Abstract: (261 Views) |
Introduction: Chronic kidney disease (CKD) is a leading cause of death and morbidity in developed countries. Although, recent studies have shown that the prevalence of thyroid disorders is higher in the individuals with CKD, however, the underlying mechanisms is not clear. Evaluation the blood levels of thyroid hormones in diabetic (diabetes type 2) and non-diabetic patients with end stage renal disease (ESRD) on hemodialysis was the objective of the current study.
Methods and Materials: The serum thyroid hormone levels including thyroid stimulating hormone (TSH), 3, 5, 3', 5'-tetraiodothyronine (T4/thyroxine) and 3, 3', 5-triiodothyronine (T3) were measured using the enzyme-linked immunosorbent assay (ELISA) method. Furthermore, kidney function tests (urea and creatinine), uric acid, serum lipid profile (total cholesterol, low density lipoprotein cholesterol/LDLc, high density lipoprotein cholesterol/HDLc and triglyceride) and fasting blood glucose/FBS have been measured using spectrophotometry-based methods.
Results: Although the differences in the levels of thyroid function hormones, including TSH, T4 and T3, in hemodialysis-diabetic subjects (HDS) were not statistically significant as compared to hemodialysis-non-diabetics (HNDS), however, the ratio of triiodothyronine (T3) to thyroxine (T4) i.e. T3/T4 ratio was significantly different in both genders (p-value<0.05). For women, this ratio (mean±standard error of the mean) was 0.220±0.026 and 0.554±0.12 in HDS as compared to the HNDS, respectively. For men, this ratio was 0.205±0.01 and 0.295±0.05 in HDS in comparison with HNDS, respectively.
Conclusion: There is a difference in the T3/T4 ratio hemostasis in HDS in comparison with HNDS and it is not related to the hypothalamic-pituitary-thyroid axis and maybe peripheral factors including enzymes such as iodothyronine deiodinase type 1 and type 2, which are involved in the regulation of serum thyroid hormone levels, are responsible for the observed differences.
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| Keywords: Chronic kidney disease, Triiodothyronine, Thyroxine, TSH, T3/T4 ratio, Diabetes |
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Full-Text [PDF 385 kb]
(29 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/25 | Accepted: 2023/08/10 | Published: 2023/08/10
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