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Central nervous system regeneration following neurological conditions with a focus on neural stem cells: Fact or Fiction
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Mohammad Karimipour   , Zahra Shabani , Mahsa Hasanzadeh Moghaddam , Farzaneh Hijroudi , Reza Rahbarghazi |
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Abstract: (235 Views) |
Introduction: Neurological disorders were presented as acute and chronic conditions in which neurons and glial cells are lost in the central nervous system (CNS). For a long time, it was unacceptable based on general incredulity. The discovery of adult neurogenesis in rodents, mammals, and even the human brain gave a hopeful perspective to the field. Neural stem cells (NSCs) are multipotent cells that have the capacity to produce themselves and could differentiate into neurons, astrocytes, and oligodendrocytes in physiological conditions. In recent years, a plethora of studies and experiments have precisely demonstrated that the NSCs exist in the discrete regions of the sub-ventricular zone (SVZ) of the brain's lateral ventricles and the sub-granular zone (SGZ) of the dentate gyrus of the hippocampus. Further, detailed assays and well-documented studies revealed that the NSCs could induce neurogenesis, neuro-regenerative mechanisms, and functional recovery in neurological disorders in -vitro and in-vivo settings. Also, the regulation and control of the behavior of NSCs in any pathological condition is a key and critical point in the context of the regenerative medicine field. In the recent decade, particularly in the previous five years, some evidence of adult neurogenesis has been shown in the human brain by means of neuro-tracing techniques and postmortem analysis. These important findings have triggered major breakthrough research in the regenerative potential of the CNS and are most likely to point out the bright future of the regenerative medicine field.
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| Keywords: CNS, NSCs, Adult neurogenesis, Human brain, Neuro-regeneration |
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Full-Text [PDF 255 kb]
(34 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/24 | Accepted: 2023/08/10 | Published: 2023/08/10
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