|
Stem Cell Therapy for Neurological Disorders: Advances, Challenges, and Future Directions
|
Fereshteh Farajdokht   |
|
|
|
Abstract: (235 Views) |
Introduction: Stem cell therapy holds great promise for the treatment of neurological disorders such as Parkinson's disease, stroke, multiple sclerosis, and spinal cord injury. Stem cells are able to differentiate into various cell types, including neurons and glial cells, and can replace damaged or dead cells, thereby restoring function and improving symptoms. Recent studies have shown that neural stem cell therapy can improve motor function, reduce inflammation, improve cognitive function, and promote neuronal survival in animal models. Stem cells can also promote neural repair through various mechanisms, including secreting growth factors, modulating the immune system, and regenerating neural stem cells, which can slow or halt the progression of neurodegenerative disorders. Despite its potential benefits, the success rate and timeline for results from stem cell therapy vary depending on the disorder, the type of stem cells used, and patient response. The stem cell secretome, a collection of growth factors and molecules, has gained increasing attention in recent years. These factors can stimulate the growth and survival of neurons, promote the formation of new blood vessels, and support nerve growth, providing a way to harness the benefits of stem cells without the risks associated with using live cells. It is important to note that stem cell therapy is still an area of active research, and further studies are needed to determine the optimal treatment protocols, long-term safety and effectiveness for neurodegenerative disorders. Future directions include the development of better methods for delivering stem cells to the site of injury or disease in the nervous system and the identification of biomarkers that can predict patient response to stem cell therapy. Overall, stem cell therapy is an exciting area of research for scientists and a hopeful prospect for patients with neurological disorders.
|
|
| Keywords: Stem cell, Neurological disorders, secretome, regeneration |
|
|
Full-Text [PDF 252 kb]
(29 Downloads)
|
Type of Study: Research |
Subject:
General
Received: 2024/02/23 | Accepted: 2023/08/10 | Published: 2023/08/10
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
