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Role of Rabies glycoprotein thorns in synaptic strength of hippocampus
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Mohammad Sayyah   , Soheil Ghassemi , Tara Asgari , Hadi Mirzapour Delavar , Hamid Gholami Pourbadie , Christophe Prehaud , Monique Lafon |
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Abstract: (256 Views) |
Introduction: Rabies is caused by the rabies virus. This virus is a neurotropic virus. The structure of rabies virus consists of five proteins. Glycoprotein G is one of these proteins that creates a part of the spines on the external surface of the virus, and by connecting and fusing with the cell membrane, it causes the virus to enter the nerve cell. A part of the carboxyl end of glycoprotein G changes the function of the host cell by activating the intracellular signaling cascades and therefore, determines the virulence of the rabies virus. In this symposium, we will review the results of investigating the effect of this glycoprotein on both short-term and long-term synaptic plasticity in the perforant pathway in the hippocampus. For this purpose, using 3rd generation viral vectors, we inserted the glycoprotein gene into the rat hippocampus and after expressing the gene in the pyramidal cells, we measured the synaptic strength in the dentate gyrus. Rabies virus glycoprotein facilitated both short-term and long-term synaptic plasticity. This finding creates a new window on how the rabies virus affects brain function.
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| Keywords: Rabies, Glycoprotein thorns, Synaptic strength, Hippocampus |
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Full-Text [PDF 248 kb]
(43 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/21 | Accepted: 2023/08/10 | Published: 2023/08/10
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