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To study the effects of intense exercise and fluoxetine on anxiety-like behaviors and the mRNA-expression of apoptotic markers in the prefrontal cortex in female rats with experimental PTSD
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Nadia Abedi   , Sakineh Shafia , Gohar Ghahramani , Moslem Mohammadi , Mohadeseh Molaee , Pardis Seyedpour |
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Abstract: (223 Views) |
Introduction: Post-traumatic stress disorder (PTSD) is a condition that develops after experiencing traumatic events. Selective serotonin reuptake inhibitors (SSRIs) are first-line treatment for PTSD. The search for effective treatment methods in this disease continues. Drug and psychotherapy treatments have achieved relatively good results at the same time, however, the efficiency of these methods is still low, even in combination with each other. Therefore, more studies are needed to identify treatments with less side effects and longer duration. The effect of exercise in improving physical and mental health has been emphasized in various studies, but the appropriate intensity of exercise is still in question. The aim of this study is to compare the effect of intense exercise and fluoxetine on behavioral and molecular damage caused by a standard model of PTSD.
Methods and Materials: Single prolonged stress was used as a model to induce PTSD, (restrained for 2h, forced to swim for 20 min, and loss of consciousness with ether) and were then kept undisturbed for 14 days. Exercise (15 m/min for 60 min/day) and drug (10 mg/kg/day) intervention was done for 4 weeks. After performing the anxiety test, the animals were killed under deep anesthesia, prefrontal cortex was extract and frozen to measure apoptotic factors by RT-PCR method.
Results: SPS rats showed an increase in anxiety levels and increased apoptosis in the prefrontal cortex. Exercise and Fluoxetine intervention reduced the injuries caused by SPS. The effect of fluoxetine was more pronounced than the effect of high-intensity exercise, and it is possible that the drug played a more important role in the groups that were affected by both.
Conclusion: It is possible that intense exercise will not be able to produce significant effects, due to side effects such as fatigue and possibly activated oxidative processes.
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| Keywords: Post-traumatic stress syndrome, single prolonged stress, intense exercise, anxiety, apoptosis |
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Full-Text [PDF 259 kb]
(29 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/11 | Accepted: 2023/08/23 | Published: 2023/08/23
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