Introduction: Parkinson’s disease (PD) is an age-associated, progressive, and common neurodegenerative disorder. It is characterized by dopaminergic neuron degeneration in the substantia nigra pars compacta. The involvement of oxidative stress, inflammation, and dysbiosis in PD has been confirmed and probiotics also have the ability to regulate the mentioned mechanisms. Here, we assessed probiotics mixture effects on learning and memory in experimental model of PD. Methods and Materials: In this experimental study, thirty male Wistar rats were divided into three groups for a 14-day treatment: sham group, untreated Parkinson group and group treated with probiotics (containing Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus reuteri, and Lactobacillus fermentum). Parkinson was induced by injection of 6-hydroxydopamine (6-OHDA). Seven days after surgery, spatial learning and memory were evaluated using the Morris water maze. Results: PD rats significantly showed higher escape latency compared to sham rats (P=0.039). However, administration of probiotic led to a decrease in escape latency compared to PD rats (P<0.0001). Results from the probe trial are evaluated to memory consolidation. The target zone preference declined significantly in the PD group (P=0.023). However, treatment with probiotic significantly prevented the memory dysfunction as indicated by increasing the time spent in the target quadrant (P<0.0001). Conclusion: These findings revealed that probiotics supplementation could be an appropriate complementary treatment for PD.
Talebi Taheri A, Tamtaji O R, Taghizadeh M, Azami Tameh A. The effects of probiotics on learning and memory in animal model of 6-hydroxydopamine-induced Parkinson’s disease. Koomesh 2023; 25 (5) :678-678 URL: http://koomeshjournal.semums.ac.ir/article-1-8870-en.html