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Cognitive-enhancing effect of aqueous fruit extract of Ziziphus jujuba in animal model of Parkinson's disease induced by 6-hydroxydopamine: behavioral and biochemical study
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Abdolkarim Talebi Taheri   , Omid Reza Tamtaji , Mohsen Taghizadeh |
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Abstract: (227 Views) |
Introduction: Parkinson’s disease (PD) is a progressive degeneration of the dopaminergic neuron that leads to bradykinesia, hypokinesia, tremor, and cognitive dysfunction. The administration of Z.jujuba in animal models of nervous system disorder had favorable effects on memory ability and oxidative stress biomarkers. The current study was, therefore, done to determine the effects of Z.jujuba aqueous extract administration on learning, memory and oxidative stress biomarker in animal model of Parkinson’s disease.
Methods and Materials: Forty adult Wistar rats were allocated in the following four groups: sham group, untreated Parkinson group and two groups treated with aqueous extract of Z.jujube at doses of 500 and 1000 mg/kg/days. Parkinson was induced by injection of 6-hydroxydopamine (6-OHDA). Rotations activity was assessed by injection of apomorphine. Spatial learning and memory were evaluated using the Morris water maze.
Results: Our data showed that Parkinson's disease induced by 6-hydroxydopamine led to the learning, memory and rotations activity dysfunctions. Administration of Z.jujube at a dose of 1000 mg/kg improved the learning and memory. In addition, Z.jujube at doses of 500 and 1000 mg/kg decreased the apomorphine-induced rotations. Also, Z.jujube decreased lipid peroxidation in midbrain and hippocampus.
Conclusion: Overall, we demonstrated that administration of Z.jujube aqueous extract in animal model of PD had favorable effects on learning, memory, apomorphine-induced rotations and markers of oxidative stress. |
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| Keywords: Ziziphus jujube, Learning, Memory, Parkinson’s disease |
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Full-Text [PDF 338 kb]
(25 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/9 | Accepted: 2023/08/23 | Published: 2023/08/23
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