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The effect of statin treatment on reinstatement of morphine induced conditioned place preference in rats
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Shiva Hashemizadeh   , Niloofar Aghajani , Hossein Azizi , Saeed Semnaninan |
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Abstract: (234 Views) |
Introduction: Opioid addiction is a chronic and relapsing disorder that can be difficult to overcome. Even after extended periods of abstinence, individuals remain at high risk for relapse. Despite efforts to use gold standard therapies for the treatment of morphine addiction, their efficacy has been underwhelming. High rates of relapse highlight the need for novel treatment strategies that can help individuals overcome their addiction and achieve long-lasting recovery. Recent reports suggests that statins, a class of drug used to reduce cholesterol level in the blood, provide therapeutic benefits for several central nervous system disorders. The present study is aimed to investigate whether statins could serve as novel pharmacological intervention agents are associated to reduce risks of reinstatement of morphine seeking behavior.
Methods and Materials: In this study, conditioned place preference (CPP) paradigm with an extinction period of 8 days was used. Adult male Wistar rats were underwent 3 days morphine (5 mg/kg) administration to acquisition morphine preference. Following morphine acquisition, we implemented three animal subgroups including statin 0.1 mg/kg, statin 1.0 mg/kg and vehicle. All the rats were treated 1 h before extinction training during the drug abstinence period, which were re-exposed to the drug in the CPP paradigm for relapse observation. CPP scores were assessed during the extinction, and relapse phases.
Results: Our results show that in rats with established morphine preference, daily statin administration at both 0.1 and 1 mg/kg dose significantly facilitated extinction of morphine reward related behavior compared to the vehicle group. Furthermore, statin at 1 mg/kg dose could prevent priming dose-induced reinstatement of extinguished morphine conditioned place preference in rats.
Conclusion: Our findings suggest that extinction training combined with the pre-extinction statin treatment can reduce the extinction of morphine-associated behavior and attenuates morphine relapse in rodents, making statin as a putative therapeutic candidate in morphine relapse prevention. |
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| Keywords: Conditional place preference, Morphine, Statin, Extinction, Reinstatement |
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Full-Text [PDF 258 kb]
(30 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/9 | Accepted: 2023/08/23 | Published: 2023/08/23
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