Introduction: Drug poisoning is one of the most common causes of hospital admission and the main cause of death, which can be reduced with timely prevention and treatment. The purpose of this review is to investigate the state of drug poisoning in different age groups. Methods and Materials: This review was conducted in 1402. PubMed, Google Scholar and Scopus databases were searched using the keywords poisoning, drugs, and drug poisoning. The articles that were published between 2010 and 2023 were extracted. A total of 20 articles were collected. By removing irrelevant articles, finally, 14 articles were examined. Results: Drug poisoning is the most common type of poisoning worldwide, which can be intentional or unintentional in nature. The unintentional type occurs due to drug interactions, physiological problems of the body such as liver and kidney failure, and improper use by children and adults over 50 years of age, and the intentional type occurs due to excessive drug consumption by adults for self-poisoning and suicide and it is mostly seen in teenagers and young adults. Based on the data obtained from the reviewed articles, 78% of the drug poisoning cases were intentional and suicidal, and 20.2% of the cases had a history of mental problems. The most common drugs used for poisoning include tricyclic antidepressants (21%), benzodiazepines (15.1%), opioids (7.9%) and tramadol (7.1%). Conclusion: Due to the high prevalence of cases of poisoning and its complications, it is necessary to inform about reducing the use of drugs that cause poisoning and prevent easy access to drugs without a prescription. Also, among other things, we can mention more attention to high-risk groups, providing consulting services, providing necessary training on how to distribute and store drugs, and using the system for recording drug poisoning cases by managers.