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Effect of clove mouthwash on the incidence of ventilator-associated pneumonia in intensive care unit patients: A comparative randomized triple-blind clinical trial
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Monir Nobahar   , Mojgan Jahanshir , Raheb Ghorbani , Farhad Malek |
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Abstract: (248 Views) |
Introduction: Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections in intensive care units (ICUs) and the use of mouthwash is the most widely used method to prevent its incidence. The aim of this study was to investigate effect of clove mouthwash on the incidence of VAP in the ICU.
Methods and Materials: This triple-blind, comparative randomized, clinical trial was conducted on 168 eligible ICU patients at Kosar Hospital in Semnan, Iran, during 2021-2022, who were divided into intervention and control groups using random blocks. The intervention group received clove extract mouthwash at 6.66% concentration and the control group received chlorhexidine 0.2% twice a day for five days (routine care). Data were collected using a demographic questionnaire, and disease severity was measured based on the Acute Physiology and Chronic Health Evaluation II (APACHE II) score, oral health status was examined using the Beck Oral Assessment Scale (BOAS), and VAP diagnosis was made based on the Modified Clinical Pulmonary Infection Score (MCPIS).
Results: Before the intervention, there was no significant difference in disease severity (p=0.412) and oral health status (p=0.239) between the patients in the two groups. After the intervention, 20.2% of the patients in the intervention group and 41.7% of those in the control group acquired VAP. The risk of VAP was 2.06 times higher in the control group than the intervention group (p=0.005, 95%, CI:1.26-3.37, RR=2.06), but the severity of VAP did not differ significantly between the patients in the two groups (p=0.557).
Conclusion: The findings showed that clove mouthwash reduces the incidence of VAP significantly. Clove mouthwash can be used as a simple and low-cost method to prevent VAP in ICU patients.
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| Keywords: Chlorhexidine, Clinical trial, Clove, Intensive Care Unit, Mouthwash, Patients, Ventilator-Associated Pneumonia |
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Full-Text [PDF 274 kb]
(33 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/7 | Accepted: 2023/08/23 | Published: 2023/08/23
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