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Unraveling the complexities of geriatric pharmacology: navigating medication challenges in aging populations
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Shadi Sarahroodi   |
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Abstract: (237 Views) |
Introduction: Geriatric pharmacology, the branch of medical science concerned with the study of drugs and their effects on the elderly, is an intricate field that warrants meticulous investigation. The physiology of older adults undergoes significant alterations, leading to a myriad of challenges when managing medication regimens. For example, the aging process diminishes the liver and kidney functions, which are crucial for metabolizing and eliminating drugs. Consequently, older adults are often more susceptible to adverse drug reactions and interactions. Additionally, the elderly commonly have multiple comorbidities, necessitating polypharmacy, which involves the concurrent use of several medications. Polypharmacy increases the likelihood of drug-drug interactions and complicates medication management.
Methods and Materials: Patient education is an essential component in addressing these challenges. Ensuring that these patients are well-informed about their medications may facilitate adherence and reduce errors. Moreover, healthcare professionals should prioritize deprescribing, which entails the systematic discontinuation of medications that are no longer necessary or beneficial. This practice can minimize the risks associated with polypharmacy.
Results: Another significant concern is the potential underrepresentation of the elderly in clinical trials. These studies often exclude older adults, particularly those with multiple comorbidities. This underrepresentation can lead to a lack of understanding of how medications affect this demographic, further complicating geriatric pharmacology.
Conclusion: In conclusion, geriatric pharmacology is a complex field due to physiological changes associated with aging and the challenges posed by polypharmacy. Patient education, deprescribing, and ensuring the inclusion of the elderly in clinical trials are essential strategies for navigating medication challenges in aging populations. Through a concerted effort among patients, caregivers, and healthcare professionals, we can work towards optimizing medication management for the elderly.
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| Keywords: Geriatric Pharmacology, Polypharmacy, Deprescribing, Senescence, Medication Stewardship |
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Full-Text [PDF 255 kb]
(32 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/6 | Accepted: 2023/08/23 | Published: 2023/08/23
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