|
The role of environmental risk factors in Alzheimer's disease
|
Fateme Karimi Firouzjaei   , Mohammad Amin Mashayekh pour , Erfan Shabani , Mohammad Rassoul Jamshidi Burkhani |
|
|
|
Abstract: (237 Views) |
Introduction: While aging and inherent genetic predisposition play a significant role in the onset of Alzheimer's disease (AD), environmental factors such as smoking, exposure to noise and obesity in midlife, lack of physical activity, alcohol consumption, depression, and lifestyle choices also play a crucial role in the risk, onset, and progression of the disease. Our goal is to increase awareness of environmental factors as contributors to the onset and progression of AD, which can be addressed to reduce many of these risk factors and improve one's health.
Search Method: This study examined articles that were produced between the years 2014 and 2023 AD and published in reputable journals. PubMed and Google Scholar websites were used for searching the articles.
Results: After reviewing the articles, it was observed that these potential risk factors such as noise exposure, sleep disorders, alcohol consumption, etc., may contribute to the pathogenesis of AD by facilitating Aβ deposition in the hippocampus. However, further studies are necessary to accurately identify the risk of neurodegenerative damage and the mechanisms involved in this process. Nonetheless, some data are controversial, and it is necessary to investigate the underlying mechanisms of AD-related pathological processes. More research is needed to elucidate the potential cognitive effects of alcohol consumption in the development of neurological diseases, including Alzheimer's, ultimately leading to potential treatments for these neurological conditions.
Conclusion: According to conducted studies, environmental factors, acting as sensitizers or triggers, play a significant role in most cases. Therefore, awareness of the risks associated with exposure to these environmental factors, coupled with well-designed epidemiological studies, is crucial for preventing the development of various neurological diseases worldwide.
|
|
| Keywords: brain, Alzheimer's disease, environmental risk factors, amyloid-β plaques |
|
|
Full-Text [PDF 329 kb]
(29 Downloads)
|
Type of Study: Research |
Subject:
General
Received: 2024/02/5 | Accepted: 2023/08/23 | Published: 2023/08/23
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
