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Beneficial effects of two dietary programs on kidney health in postmenopausal acute kidney injury: apoptosis and histopathological study
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Fatemeh Darvishzadeh Mahani   , Mohammad Khaksari , Maryam Iranpour , Zahra Soltani , Alireza Raji-Amirhasani , Zahra Hajializadeh |
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Abstract: (223 Views) |
Introduction: Lifestyle and eating habits affect the health and function of body organs such as kidneys. The aim of this study was to investigate the effect of two types of diet programs, calorie restriction (CR) and time restriction (TR) on histopathological changes and apoptotic molecules during acute kidney injury (AKI) in postmenopausal rats.
Methods and Materials: The female rats were divided into two groups, ovariectomized (OVX) and ovary-intact (sham), and were placed on CR and TR diets for 8 weeks; After that, AKI was induced by injection of glycerol. Functional and apoptotic indices and histopathological changes, were measured before and after AKI.
Results: After AKI, urinary albumin excretion, serum urea, creatinine, kidney tissue Bax and Bax/Bcl2 ratio increased, while GFR and kidney tissue Bcl2 decreased compared to before AKI. Histopathological indices (inflammation, cellular necrosis, cell vacuolization, tubular dilatation, intratubular cast and congestion) also confirmed renal injury. CR and TR diets improved renal injury indices and prevented an increase in the Bax/Bcl2 ratio. The histopathological results also showed the improvement of kidney condition in both groups, especially in the CR diet.
Coclution: The results indicated that CR and TR programs have renoprotective effects against AKI and may increase the resistance of kidney cells to injury by reducing the Bax / Bcl2 ratio and improving apoptosis. But the effects of CR are more than TR.
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| Keywords: Acute kidney injury, Calorie restriction, Time restriction, Apoptosis, Histopathological finding, Diet |
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Full-Text [PDF 257 kb]
(33 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/4 | Accepted: 2023/08/23 | Published: 2023/08/23
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