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High-Intensity Interval Training mitigates Oxidative Stress and Inflammation in Methotrexate-Induced Lung injury
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Maryam Doustaki Zaboli   , Mohammad-Abbas Bejeshk , Hamid Najafipour , Mohammad Amin Rajizadeh , Mahdiyeh Haj Hosseini , Mina Bahrami , Faegheh Bahri , Fahimeh Rostamabadi |
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Abstract: (243 Views) |
Introduction: In this study, we aimed to explore the potential therapeutic benefits of high-intensity interval training (HIIT) in mitigating lung damage caused by methotrexate. Methotrexate, a medication used in the treatment of cancer and immune diseases, has been linked to oxidative stress and inflammation, leading to lung injury. Given the anti-inflammatory and antioxidant properties of HIIT, we sought to examine its effects on this specific type of injury.
Methods and Materials: A total of 70 male Wistar rats were divided randomly into four groups: CTL (Control), HIIT (High-intensity intermittent training), ALI (Acute lung injury), and ALI+HIIT (Treated with HIIT). ALI group rats received Mtx at a dose of 20 mg/kg i.p once to induce acute lung injury. The High-intensity intermittent training was carried out for a duration of eight weeks. Upon completion, the levels of Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD), Glutathione Peroxidase (Gpx), Interleukin 10 (IL-10), and Tumor Necrosis Factor-Alpha (TNF-A) were evaluated.
Results: The administration of Methotrexate resulted in an elevation of TNF-α and MDA levels, while causing a reduction in the levels of TAC, SOD, Gpx, and IL-10. Conversely, the use of High-Intensity Interval Training (HIIT) led to a decrease in the levels of oxidative and inflammatory factors. Simultaneously, HIIT enhanced the levels of antioxidant and anti-inflammatory factors.
Conclusion: According to the results, HIIT could improve acute lung damage caused by methotrexate through reduction of the level of oxidant and inflammatory factors and ameliorating pulmonary edema.
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| Keywords: Methotrexate, High-intensity intermittent training, acute lung injury, oxidative stress, inflammatory factors |
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Full-Text [PDF 328 kb]
(35 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/4 | Accepted: 2023/08/23 | Published: 2023/08/23
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