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Bee Venom as a Promising Therapeutic Strategy in Central Nervous System (CNS) Diseases
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Zeinab Vahidinia   |
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Abstract: (224 Views) |
Introduction: Central nervous system (CNS) disorders are one of the leading health problems today, accounting for a large proportion of global morbidity and mortality. Most these disorders are characterized by high levels of oxidative stress and intense inflammatory responses in affected tissues. While extensive research has been conducted on CNS diseases, but few breakthroughs have been made in treatment methods. To date, there are no disease-modifying drugs available for treatment, underscoring the urgent need for finding effective medications. Bee venom (BV), which is produced by honeybee workers' stingers, has been a subject of interest and study across various cultures. Over the past few decades, extensive research has focused on BV and its therapeutic potential. It is a typical toxin made up of a variety of substances, mainly proteins and peptides, and, in very low concentrations, other types of molecules. Among the compounds found in BV, melittin and phospholipase A2 (PLA2) are most prevalent and extensively studied. Research has proven that bee venom is effective in various medical conditions, including pain, arthritis and inflammation and CNS disorders such as Multiple sclerosis, Alzheimer's disease and Parkinson's disease. This review provides a comprehensive overview of the existing knowledge concerning the therapeutic effects of bee venom and its primary compounds on various central nervous system diseases. Additionally, we aim to shed light on the potential mechanisms underlying these effects.
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| Keywords: Bee venom, Central nervous system disorders, Melittin, Phospholipase A2 |
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Full-Text [PDF 252 kb]
(29 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/3 | Accepted: 2023/08/23 | Published: 2023/08/23
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