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The effect of simvastatin in prevention of cognitive deficits in trimethyltin-induced Alzheimer’s like model in the rat
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Adel Salari   , Mehrdad Roghani , Mohsen Khalili , Mahdieh Taheri |
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Abstract: (233 Views) |
Introduction: Simvastatin is reported to improve cognition and to slow down progression of Alzheimer's disease. Trimethyltin (TMT), an organotin compound with neurotoxicant effects, selectively damages limbic system, especially the hippocampus. Animals exposed to trimethyltin develop behavioral alterations (hyperactivity and aggression), cognitive impairment (memory loss and learning impairment) and spontaneous seizures. Simvastatin is a drug with neuroprotective effect. This study was done to assess the effect of simvastatin in prevention of cognitive deficits in trimethyltin-induced Alzheimer’s like model in the rat.
Methods and Materials: In this experimental study, 40 male Wistar rats (200-250 g) were randomly divided into 5 groups: control, control treated with Simvastatin at dose of 30 mg/kg, TMT, TMT treated with Simvastatin at doses of 10 or 30 mg/kg. Five groups of animals, each consisting of 8 rats were tested by novel object recognition, Y maze, passive avoidance paradigm, and the Barnes maze. Trimethyltin was administered i.p. (8 mg/kg, once) and simvastatin was daily given p.o 1 h after TMT for 3 weeks at doses of 10 or 30 mg/kg. Cognitive performance was assessed in various behavioral tests.
Results: Administration of simvastatin to TMT group at a dose of 30 mg/kg significantly and partially increased discrimination index in novel object recognition, improved alternation in short-term Y maze, increased step-through latency in passive avoidance paradigm, and also reduced probe trial errors and latency in the Barnes maze task.
Conclusion: Our results suggested that simvastatin may be useful to prevent cognitive decline due to neurotoxicants such as TMT.
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| Keywords: Trimethyltin, Simvastatin, Alzheimer's disease, Cognitive |
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Full-Text [PDF 378 kb]
(36 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/2 | Accepted: 2023/08/23 | Published: 2023/08/23
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