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Effects of Berberine on Inflammatory Cytokine in Lung Ischemia Reperfusion Injury
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Fateme Keshavarz   , Gholamreza Sepehri , Mohammad Abbas Bejeshk , Hamid Najafipour , Mohammad Khaksari , Ali Mahyaei , Fatemeh Sadat Moosavi , Morteza Gholami Sakol , Mohammad Yousefi Zardak |
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Abstract: (250 Views) |
Introduction: Lung Ischemia reperfusion injury (LIRI) is a severe complication associated with heart bypass surgery and lung transplantation that affects many patients annually. Berberine (BBR), a quinoline alkaloid, has shown beneficial effects (anti-inflammatory) in various pharmacological actions. This study was conducted with the aim of investigating the potential anti-inflammatory and protective effects of berberine in inflammation caused by lung ischemia-reperfusion injury.
Methods and Materials: Wistar rats were divided into four groups) Sham, lung ischemia reperfusion, Vehicle+LIR, BBR+LIR) and administered intraperitoneal 30 mg/kg berberine for one week before undergoing LIR. The assessment included analysis of inflammatory cytokine levels (IL-6: Interleukin 6 and, TNF-α: Tumor necrosis factor alpha), lung edema.
Results: Compared to the sham group, the LIR group demonstrated increased inflammatory cytokines, including TNF-α and IL-6. Moreover, the lung edema index (w/d ratio) exhibited a significant increase. However, BBR administration effectively reduced the levels of TNF-α, IL-6, and the w/d ratio.
Conclusion: BBR demonstrated inhibitory effects on inflammatory responses induced by ischemia-reperfusion injury in the lungs of adult rats.
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| Keywords: Lung ischemia-reperfusion injury, Berberine |
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Full-Text [PDF 333 kb]
(40 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/1 | Accepted: 2023/08/23 | Published: 2023/08/23
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