|
Investigating the Oxidant and Antioxidant Effects of Quercetin in Asthma: A Rat Model Study
|
Fatemeh Sadat Moosavi   , Hossein Pourghadamyari , Mohammad Abbas Bejeshk , Mohammad Amin Rajizadeh , Hamid Najafipour , Ali Mahyaei , Fateme Keshavarz , Marteza Gholami Sakol , Mohammad Yousefi Zardak |
|
|
|
Abstract: (229 Views) |
Introduction: Asthma is a chronic inflammatory disease. Reactive oxygen species (ROS), endogenous nitric oxide (NO) and NO-derived reactive nitrogen species (RNS) have been reported to mediate oxidative stress and airway inflammation. Oxidant and antioxidant play an important role in this disease. In this study, the oxidant and antioxidant effects of quercetin were investigated in rats with asthma.
Methods and Materials: The asthma was induced by ovalbumin (OVA). Rats were allocated into four groups: Control (Ctl), Asthma+Vehicle, Asthma+Dexamethasone (Asthma+DX) and Asthma + Quercetin (Asthma+Q). Quercetin (50 mg/kg) or Dexamethasone (2.5 mg/kg) were injected intraperitoneally once a day for one week, after inducing asthma. And oxidative stress indices (MDA, CAT, GPX, SOD and TAC) were evaluated in tissue and serum. Also, the gene expression of TGFβ, α-SMA in the tissue was checked.
Results: The results of this study showed that quercetin decreased expression TGFβ and α-SMA in asthma, in addition, quercetin improved oxidative stress by decreasing the level of MDA and increasing the level of SOD, CAT, TAC, and GPX in serum and lung tissue.
Conclusion: Our results showed the anti-oxidative and impacts of quercetin especially, at the lung tissue level and also our findings revealed that quercetin has significant protective impacts against asthma.
|
|
| Keywords: Asthma, Quercetin, Oxidative stress |
|
|
Full-Text [PDF 348 kb]
(35 Downloads)
|
Type of Study: Research |
Subject:
General
Received: 2024/02/1 | Accepted: 2023/08/23 | Published: 2023/08/23
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
