|
Effect of salep root on ethylene glycol-induced kidney stones
|
Vida Khalafi   , Hassanali Abedi , Hossein Kargar Jahromy |
|
|
|
Abstract: (246 Views) |
Introduction: The aim of this study was to investigate the effects of aqueous extracts of Salep root on ethylene glycol and ammonium chloride-induced kidney stones in a rat model.
Methods and Materials: A total number of 64 male Wistar rats were randomly divided into four groups equally: Group I (normal control), Group II (disease control), and Groups III and IV (treatment groups). Group I received tap drinking water, and groups II, III, and IV received 1% ethylene glycol plus 0.25% ammonium chloride in drinking water for 28 days. Group III received intra-peritoneal injections of 320 mg/kg aqueous extracts from the 14th day of the experiment. Group IV was given intra-peritoneal injections of 640 mg/kg aqueous extracts from the 14th day of the experiment. After 28 days the amount of uric acid and creatinine in urine was experimented with by metabolic cage in 24h. Additionally, the kidneys were removed and observed for tubulointerstitial changes and calcium oxalate (CaOx) deposits.
Results: Treating by the aqueous extracts of salep root decreased tubulointerstitial damage and CaOx deposits in treatment groups (P<0.001). The amount of uric acid and creatinine in urine was increased in group II and was decreased in groups III and IV (P<0.001). In addition, high dosed treatment group seemed to be more effective (P<0.001).
Conclusion: Salep root extracts due to anti-inflammatory and antioxidant effects improved tubulointerstitial damage and prevented and treated CaOx stone.
|
|
| Keywords: Salep, Calcium oxalate (CaOx), Ethylene glycol, kidney, rat |
|
|
Full-Text [PDF 254 kb]
(33 Downloads)
|
Type of Study: Research |
Subject:
General
Received: 2024/01/31 | Accepted: 2023/08/23 | Published: 2023/08/23
|
|
|
|
|
|
|
| Add your comments about this article |
|
|
|
