|
A Review on garlic as a supplement for Alzheimer’s Disease: A mechanistic insight into its direct and indirect effects
|
Mohammad Mahdi Ghazimoradi   , Mozhgan Ghobadi Pour , Ehsan Ghoushi , Hadise Karimi Ahmadabadi , Mahmoud Rafieian-Kopaei |
|
|
|
Abstract: (242 Views) |
Introduction: Alzheimer’s disease (AD) is one of the most complicated neurodegenerative diseases causing dementia in human beings. Aside from that, the incidence of AD is increasing and its treatment is very complicated. There are several known hypotheses regarding the pathology of Alzheimer’s disease, including the amyloid beta hypothesis, tau hypothesis, inflammation hypothesis, and cholinergic hypothesis, which are investigated in different research to completely elucidate the pathology of AD. Besides, some new mechanisms, such as immune, endocrine, and vagus pathways, as well as bacteria metabolite secretions, are being explained as other causes to be somehow related to AD pathogenesis. There is still no definite treatment for Alzheimer’s disease that can completely cure and eradicate AD. Garlic (Allium sativum) is a traditional herb used as a spice in different cultures, and due to the organosulfur compounds, like allicin, it possesses highly anti-oxidant properties.
Methods and Materials: the benefits of garlic in cardiovascular diseases, like hypertension and atherosclerosis, have been examined and reviewed, although its beneficiary effects in neurodegenerative diseases, such as AD, are not completely understood. In this review, we discuss the effects of garlic based on its components, such as allicin and S-allyl cysteine, on Alzheimer’s disease and the mechanisms of garlic components that can be beneficiary for AD patients, including its effects on amyloid beta, oxidative stress, tau protein, gene expression, and cholinesterase enzymes.
Results: According to the review of the literature, it has beneficial effects, especially in animal studies on Alzheimer's disease.
Conclusion: However, more studies should be done on humans to find the exact mechanisms of garlic’s effects on AD patients.
|
|
| Keywords: Alzheimer's disease, Garlic, Allicin, S-allyl cysteine, Amyloid beta, Tau protein |
|
|
Full-Text [PDF 380 kb]
(26 Downloads)
|
Type of Study: Research |
Subject:
General
Received: 2024/01/28 | Accepted: 2023/08/1 | Published: 2023/08/1
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
