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Effect of levothyroxine on motor activity against 3-nitropropionic acid (3-NP)-induced experimental Huntington’s disease in rats
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Mohammad Ali Mirshekar   , Fereshteh Badini |
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Abstract: (262 Views) |
Introduction: Huntington’s disease (HD) is a neurodegenerative disorder characterised by motor and cognitive impairments. Considering the role of thyroid hormones in the development and function of neural, this study aimed to investigate the effect of levothyroxine (L-T4) against (3-NP) induced neurobehavioral alterations in animals.
Methods and Materials: Adult male Wistar rats were randomly assigned into six groups (8 in each group): Group 1 (control) received physiological saline intraperitoneally (ip). Groups 2 and 3 received L-T4 (30 and 100 μg/kg, ip, respectively) daily for 7 days. Group 4 (HD) received 3-nitropropionic acid (3-NP) (25 mg/kg, ip) daily for 7 days. Groups 5 and 6 received L-T4 (30 and 100 μg/kg, ip) 30 min after 3-NP (25 mg/kg, ip) injection for the same duration. After twenty-four hours of the last dose, to assess the effect of L-T4 on motor activity, rats were subjected to Open Field Test (OFT) behavioral.
Results: L-T4 treatment in 30 and 100 μg /kg doses groups significantly improved motor activity. In OFT, the number of line crossings and rearing increased after L-T4 administration in HD rats. Also, L-T4 administration significantly reduced immobility time in HD rats.
Conclusion: Our results showed the potential advantageous effect of L-T4 administration in attenuating HD symptoms in rats. These results suggest that L-T4 might be a drug of choice to treat HD.
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| Keywords: Huntington’s disease, 3-nitropropionic acid, levothyroxine, motor activity |
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Full-Text [PDF 382 kb]
(31 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/19 | Accepted: 2023/08/23 | Published: 2023/08/23
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