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Investigating the effect of vitamin E in the treatment of paraquat-induced Parkinson's disease: A systematic review
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Fatemeh Bosak   |
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Abstract: (249 Views) |
Introduction: Paraquat (PQ) is a widely used and highly toxic herbicide that causes oxidative stress. Parkinson's disease (PD) is a common neurodegenerative disease in which dopaminergic neurons in the substantia nigra gradually die. Vitamin E is a nutrient whose antioxidant effects have been studied for years. This study was conducted to investigate the antioxidant role of vitamin E in the treatment of Parkinson's disease caused by paraquat.
Search Method: This review was conducted using the mentioned keywords and their combinations in PubMed and Google Scholar databases, and the title, full text and abstract of the selected articles were reviewed.
Results: According to this study, inflammation and oxidative stress play an important role in neurological diseases. Paraquat causes oxidative stress and is a potential neurotoxin that affects the brain and leads to the death of dopaminergic neurons, similar to what occurs in PD. The pathology of PD shows a decrease in dopaminergic neurons in the reticular part of the substantia nigra, which according to studies, this condition is seen in people after exposure to paraquat. Paraquat causes the death of cerebellar cells, which is reduced by free radical scavenger vitamin E. Administration of vitamin E can be effective in reducing cell death caused by PD. Administration of vitamin E can reduce the risk of developing PD and thus have a preventive role.
Conclusion: Paraquat causes inflammation and oxidative stress and brain cell death, which is associated with Parkinson's disease, and treatment with vitamin E can be effective in reducing cell death caused by PD.
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| Keywords: Paraquat, Parkinson's disease, oxidative stress, vitamin E, antioxidant |
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Full-Text [PDF 340 kb]
(36 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/19 | Accepted: 2023/08/23 | Published: 2023/08/23
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