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The Therapeutic Potential of Quercetin in Asthma: Unraveling its Anti-Inflammatory Properties
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Fahimeh Rostamabadi   , Hossein Pourghadamyari , Mohammad Abbas Bejeshk , Mohammad Amin Rajizadeh , Amir Hossein Doustimotlagh , Hamid Najafipour |
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Abstract: (255 Views) |
Introduction: Asthma, a persistent respiratory condition that can affect individuals of any age, is characterized by the inflammation and constriction of airway muscles, leading to breathing difficulties. In this study, we examined the potential anti-inflammatory effects of quercetin, a plant-derived compound, on inflammatory markers present in the lung tissue and serum of rats afflicted with asthma.
Methods and Materials: Asthma was induced by ovalbumin. Rats were divided into four groups: control, asthma+vehicle (received normal saline), asthma+dexamethasone, and asthma+quercetin. Following the induction of asthma, quercetin (50 mg/kg) and dexamethasone (2.5 mg/kg) were administered intraperitoneally once daily for a duration of one week. On the 50th day, various lung histopathology indices were assessed, including inflammatory factors IL-10, IL-1β, and IL-6. Additionally, the expression of GATA Binding Protein 3 (Gata-3) and Tbx21 (T-bet) genes in the lung tissue was evaluated.
Results: The findings indicated that the administration of quercetin led to a decrease in Gata3 gene expression and an increase in Tbx21 gene expression and lung histopathology indices in response to asthma. Moreover, quercetin exhibited a reduction in IL6 and TNFα levels while elevating IL10 levels within the lung tissue subsequent to asthma treatment.
Conclusion: Quercetin ameliorates inflammation caused by asthma, especially at the tissue level. Therefore, quercetin can be considered a potent antiasthmatic agent.
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| Keywords: Asthma, Inflammation, Quercetin |
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Full-Text [PDF 323 kb]
(37 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/18 | Accepted: 2023/08/23 | Published: 2023/08/23
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