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Evidence On Efficacy of Ellagic Acid in Cardiopulmonary Dysfunction Subsequent to Emphysema
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Zahra Mansouri   , Mahin Dianat , Maryam Radan , Mohammad Badavi |
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Abstract: (268 Views) |
Introduction: Emphysema is one of the chronic obstructive pulmonary diseases that leads to airflow limitation and alveolar demolition which can progress the hemodynamic changes and cardiovascular dysfunction. Oxidative stress and inflammation are the main risk factors to produce histological and functional features of emphysema. Accordingly, antioxidants may represent an attractive therapeutic approach in emphysema and subsequent dysfunctions. Therefore, the aim of this study was to investigate the possible protective effect of ellagic acid (EA), as a well-known anti-oxidant, on pulmonary arterial pressure and the development of lung and heart injuries in a rat model of Emphysema.
Methods and Materials: Sixty healthy male Sprague-Dawley rats were divided into six groups: control (saline 0.9%, 1 ml/kg, by gavage), porcine pancreatic elastase (PPE) (25 UI/kg, intratracheal), EA (10, 15, and 30 mg/kg, gavage), PPE+EA (30 mg/kg, by gavage). Right ventricular systolic pressure (RVSP) and electrocardiogram were recorded to evaluate the pulmonary hemodynamic and electrocardiogram parameters. Also, the Permeability of lung capillary and function of air blood barrier was assessed using lung water content and Broncho-Alveolar lavage fluid. Moreover, the histopathology, antioxidant profile, and oxidative stress indexes were measured in cardiac and lung tissue samples.
Results: Elastase administration caused an increase in RVSP which was in line with elevated inflammatory cells and cytokines, as well as lipid peroxidation, and decreased antioxidant levels. Also, electrocardiogram parameters significantly changed in the elastase group compared with control rats. Co-treatment with EA not only restored elastase-depleted anti-oxidant levels and prevented pulmonary arterial hypertension but also improved cardiac chronotropic and inotropic properties.
Conclusions: Our results documented that elastase administration leads to pulmonary hemodynamic change and treatment with EA, as an anti-inflammatory and anti-oxidant agent, can protect the development of lung and heart injuries induced by elastase.
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| Keywords: Cardiopulmonary, Elastase, Ellagic Acid, Emphysema, Inflammation |
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Full-Text [PDF 272 kb]
(47 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/18 | Accepted: 2023/08/23 | Published: 2023/08/23
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