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α-pinene inhibits ketamine-induced schizophrenia-like symptoms in mice
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Hakimeh Gavzan Daronkola   , Mohaddeseh Abouhosseini Tabari , Mohammad Amin Mashayekhpour , Mehdi Havazadeh , Mohammad Rassoul Jamshidi Borkhani |
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Abstract: (260 Views) |
Introduction: Schizophrenia is a chronic neurological disorder associated with psychotic symptoms, such as motivational and cognitive dysfunctions (ref). α-pinene belongs to the monoterpene class and is one of the main bioactive components of the essential oils from the plants, like conifers, Juniper ssp, and Cannabis ssp (ref). The previous documents indicated the health-beneficial effects of α-pinene, as anti-inflammatory, antioxidant, and antibiotic activities (ref). This study was conducted to investigate the potential effect of α-pinene against chronic ketamine-induced schizophrenia (SCZ) in mice.
Methods and Materials: Forty male Swiss mice (2±23 grams) were randomly divided into four groups (10 in each), including control (no treatment), Ketamine, Ketamine+α-pinene 10mg/kg, and Ketamine+α-pinene 20mg/kg. Animal received distilled water or KET (20 mg/kg) intraperitoneally (i.p), for 14 days. In addition, they were administered α-pinene (10 and 20 mg/kg) or vehicle, from the 7th to the 14th. SCZ-negetive like behavior were evaluated using the forced swimming test (FST). The data obtained were analyzed using “SPSS for Windows” software version 22.0, and expressed as the mean±SEM.
Results: Our results showed that the repeated adminstartion of ketamine increased immobility time (105±7.2) compared to control group (52±5) (P≤0.001). Treatment with α-pinene doses of 10 and 20mg/kg reduced immobility time (49±3.95 and 44.75±4.9) compared to the Ketamine group (P≤0.001).
Conclusion: so α-pinene can reverse the ketamine KET-induced behavioural deficits. It could be suggested that α-pinene is able to attenuate the negative symptom of schizophrenia.
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| Keywords: α-pinene, FST, monoterpene, ketamine, schizophrenia |
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Full-Text [PDF 486 kb]
(41 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/17 | Accepted: 2023/08/23 | Published: 2023/08/23
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