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Effects of gallic acid on memory deficits and electrophysiological impairments induced by cerebral ischemia/reperfusion in rats following exposure to ambient dust storm
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Kowsar Bavarsad   , Yaghoob Farbood , Seyed Ali Mard , Seyed Esmaeil Khoshnam , Mahin Dianat , Hamzeh Mirshekari Jahangiri , Laya Sadat Khorsandi , Gholamreza Goudarzi , Alireza Sarkaki |
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Abstract: (251 Views) |
Introduction: We aimed to investigate the probable protective effects of gallic acid (GA) on cognitive deficits, hippocampal long term potentiation (LTP) impairments, and molecular changes induced by cerebral ischemia/reperfusion (I/R) in rats following exposure to ambient dust storm.
Methods and Materials: After pretreatment with GA (100 mg/kg), or vehicle (Veh) (normal saline, 2 ml/kg) for ten days, and 60 minutes’ exposure to dust storm including PM (PM, 2000–8000 g/m3) every day, 4-vessel occlusion (4VO) type of I/R was induced. Three days after I/R induction, we evaluated behavioral, electrophysiological, histopathological and brain tissue inflammatory cytokine changes.
Results: Our findings indicated that pretreatment with GA significantly reduced cognitive impairments caused by I/R (P<0.05) and hippocampal LTP impairments caused by I/R after PM exposure (P<0.001). Additionally, after exposure to PM, I/R significantly elevated the tumor necrosis factor α content (P<0.01). Histopathological results also revealed that I/R and PM caused cell death in the hippocampus CA1 area (P<0.001) and that GA decreased the rate of cell death (P<0.001).
Conclusion: Our findings show that GA can prevent brain inflammation, and thus cognitive and LTP deficits caused by I/R, PM exposure, or both.
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| Keywords: Ambient air particulate matter, Cerebral ischemia/reperfusion, Gallic acid, Hippocampal long term potentiation, Inflammatory cytokines, Rat |
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Full-Text [PDF 396 kb]
(38 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/17 | Accepted: 2023/08/23 | Published: 2023/08/23
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