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The Effect of Microbiota on miRNA Alteration in Alzheimer's Disease: A Review Study
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Ardeshir Nabizadeh   , Zakieh Sadat Sheikhalishahi , Hamideh Asadinezhad , Hanieh Kazemi |
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Abstract: (282 Views) |
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Recent research has suggested that alterations in the gut microbiota and microRNAs (miRNAs) may play a role in its development and progression.
Search Method: Research materials were extracted from 35 articles using the following databases: Science Direct, Google Scholar, and PubMed by using combination of the keywords: Alzheimer’s disease and miRNA, dysbiosis and miRNA, microbiota and Alzheimer.
Results: The gut microbiota refers to microorganisms that have a symbiotic relationship with their host and play a crucial role in health. Recent studies have shown that alterations in gut microbiota composition (dysbiosis) can affect brain function. miRNAs are small non-coding RNA molecules that regulate gene expression by binding to mRNA and inhibiting its translation into proteins. They have been implicated in various biological processes, including cell differentiation, and immune response. Additionally, dysregulation of miRNA expression is associated with several neurological disorders, including AD. Emerging evidence suggests that gut microbiota can influence miRNA expression and function. Several miRNAs have been identified as potential biomarkers for AD, including miR-29, miR-34a, and miR-132 which regulate the neuropathology of AD. Recently found that dysbiosis can modulate these miRNA’s expression. Moreover, fecal microbiota transplantation from AD mice to healthy mice can induce changes in miRNA expression similar to those observed in AD.
Conclusion: The gut microbiota and miRNA alterations have emerged as important players in the development and progression of AD. Dysbiosis can influence miRNA expression, leading to neuronal function changes and AD pathology. Further research is needed to elucidate this interaction’s mechanisms and explore its therapeutic potential in preventing and treating AD.
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| Keywords: Alzheimer, Microbiota, miRNA, Dysbiosis |
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Full-Text [PDF 323 kb]
(49 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/14 | Accepted: 2023/08/23 | Published: 2023/08/23
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