Introduction: In neuroscience, spatial memory is a part of memory that is responsible for recording peripheral information and spatial orientation. Hippocampus and medial temporal lobe are key brain regions in spatial memory and learning. [1]. Spatial memory is a cognitive process that allows an organism to remember different positions and the spatial relationship between objects [2]. The aim of this study is to investigate the effect of brain injury by CCI on the spatial memory of rats using the Morris water maze. Methods and Materials: This experimental study was conducted on forty-eight 45-day-old adult male Wistar rats; the animals were divided into six groups of 8; 7 days control group, 28 days control group, 7 days sham group, 28 days sham group, 7 days trauma group and 28 days trauma group. The animals tried to find the hidden platform in the maze for 5 days, 4 sessions every day. The animals' spatial memory was tested by removing the hidden platform on the seventh and twenty-eighth days after the learning phase. The time spent in the maze and the distance traveled were calculated, and the data were measured by the variance analysis test with repeated measurements. Results: By examining the probe, the time spent and also the distance traveled in the target quadrant, the results of the control groups 7, control 28, sham 7 and sham 28 days, did not have a significant difference, while in both groups of Trauma 7 and 28 days, the investigated factors showed significant differences. Conclusion: According to the obtained results, brain injury causes destruction of the spatial memory in rats.
Hooshmand M, Kamrani M, Sayyah M, Gholami Pourbadie H, Asoodeh A, Zendehdel M. Investigating the short-term and long-term spatial memory of rats after brain injury. Koomesh 2023; 25 (5) :374-374 URL: http://koomeshjournal.semums.ac.ir/article-1-8541-en.html