Introduction: Swallowable smart pills as an emerging and advanced technology in pharmaceutical technology, with temporary placement in the human digestive tract, can help doctors and health specialists in their medical affairs in the process of preventing, diagnosing and treating diseases and disorders related to the digestive system. Help and cause the transformation of the way of monitoring and treating a wide range of diseases. The purpose of this study is to identify the application of smart pill technology in gastrointestinal patients. Search Method: This review study was conducted in 2023 by searching "Application", "Technology","Smart pills" and "Gastrointestinal patients" keywords in the reliable PubMed database and Google Scholar search engine without time frame. The sources of the articles were checked to ensure the completeness of the search results and duplicate titles were removed with the help of EndNote software. Results: In this study, the title and abstract of 25 articles were selected by the researchers and finally 7 articles were included in this study according to the inclusion criteria. According to studies, smart pills in the digestive tract contain very small and various electronic and mechanical parts such as batteries, microprocessors, sensors, wireless radio system, cameras, medicine tank, etc., which are able to perform missions with their help. For example: 1- Accurately tracking the movement and speed of food, 2-Automatic drug release at a specific time and place, 3-Measuring factors (pH, temperature, glucose and gas levels), 4-Sending regular reports from the digestive system to a receiver outside body (by magnetic field), 5-imaging, sampling and surgery. Conclusion: Considering the challenges of smart pills such as production and distribution costs, limited access and data security, these types of pills can provide accurate and fast data needed by doctors to diagnose digestive diseases and disorders, perform tests Clinically, more accurate and efficient treatment as well as reducing: 1-medication errors and side effects, 2- expensive diagnostic tests, 3- hospitalization, 4- invasive treatment methods and finally reducing health care costs in the field of health.