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An overview of multiple sclerosis: pathophysiology, diagnosis and new treatment studies
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Elmira Bayrami   , Baqer Jafarvand Giclo , Yusuf Taziki , Ali Mashhadi Harati , Mehdi Haji Babaei |
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Abstract: (261 Views) |
Introduction: Multiple sclerosis (MS) is one of the most common diseases of the central nervous system (CNS). This disease is accompanied by a severe disorder in the immune system, and its symptoms include the reduction of myelin, damage to axons and oligodendrocytes in the CNS. The onset of this disease is often in early adulthood and its incidence is more common in women than men. The incidence and prevalence of MS is increasing in developed and developing countries. It is often said that the cause of MS is unknown, so this disease is classified as a complex disease. Studies have shown that viral factors, environmental pollution, stress, job status, sunlight, smoking and vitamin D deficiency along with genetic background play an important role in the occurrence of this disease. The symptoms of this disease are numerous and include movement and balance symptoms, vision disorders, body pains, sensory and mental disorders, and other cases. The purpose of this article is to review the latest studies on the ways of diagnosing this disease, studies in molecular and preclinical fields, animal modeling methods and the use of neurotrophic factors to control the disease process and express the challenges in the process of these studies and provide effective suggestions.
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| Keywords: Multiple sclerosis, Myelin destruction, MS modeling, Meurotrophic factors, MS diagnosis |
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Full-Text [PDF 248 kb]
(35 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/12 | Accepted: 2023/08/23 | Published: 2023/08/23
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