Introduction: Human nature has a central role in old and new wisdom. Human nature has been talked about since the distant past in natural sciences, philosophy, mysticism and religious sciences. Also, in the treatment of diseases, there is a type of medicine known as "holistic" medicine. In this type of treatment, only one part of human existence is not considered. Since man has an interwoven existence of different areas, he needs multifaceted treatment methods for recovery. Today, a doctor usually considers a human being as a material body with anatomy, biology and physiology In the past, the soul and soul have been considered an inseparable part of human existence, that is, man was known at least with two aspects of body and soul. Search Method: It is mainly documentary and library, in addition to the reports that are available from the research of new spiritual researchers. Results: The world has many layers in terms of physicality, and also human is not a one-dimensional being, but has at least three specific layers: body, mind and soul. In the philosophies and medicine of the Far East and the philosophy of Vedanta, man has five or seven layers of existence, each of which carries a part of the works of the living being that we know as man. In Islamic philosophy and mysticism, man has seven inner layers that can be adapted to Indian philosophy. Parts of human existence other than her body contain her life, personality, feelings and emotions, will, thinking and immaterial abilities. Conclusion: From the cognitive and behavioral functions of man, we come to the conclusion that man has two physical and metaphysical domains. More precisely, this metaphysical realm can be divided into seven layers.