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p-Coumaric acid ameliorates cognitive and non-cognitive disturbances in a rat model of Alzheimer’s disease: The role of oxidative stress and inflammation
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Shahab Ghaderi   , Parsa Gholipour , Alireza Komaki , Iraj Salehi , Khodabakhsh Rashidi , Seyed Esmaeil Khoshnam , Masome Rashno |
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Abstract: (285 Views) |
Introduction: Alzheimer’s disease (AD) is the most progressive form of neurodegeneration that results in cognitive and non-cognitive disorders. Aluminum is a risk factor in the development and progression of Alzheimer’s disease. The present study was designed to determine the effects of p-coumaric acid (p-CA), a phenolic compound, on spatial cognitive ability and non-cognitive functions and to identify the role of oxidative stress and inflammation in an AD model induced by aluminum chloride (AlCl3) in rats.
Methods and Materials: Both AlCl3 (100 mg/kg/day; P.O.) and p-CA (100 mg/kg/day; P.O.) treatments were given for six consecutive weeks. During the fifth and sixth weeks of the treatment, the cognitive and non-cognitive functions of the rats were assessed using standard behavioral tests. Additionally, oxidative-antioxidative status, inflammatory markers, and histological changes were evaluated in the cerebral cortex and hippocampal regions of the rats.
Results: The study found that exposure to AlCl3 resulted in increased anxiety and depression-like behaviors, decreased locomotor/exploratory levels, and impaired spatial memory and learning. These cognitive and non-cognitive issues were accompanied by increased oxidative stress, inflammation, and neuronal loss in the brain regions studied. However, treatment with p-CA was found to alleviate all of these negative changes in the AlCl3-induced AD rat model.
Conclusion: The findings suggest that both anti-oxidative and anti-inflammatory properties of p-CA may be the underlying mechanisms behind its beneficial effect in preventing neuronal loss and improving cognitive and non-cognitive deficits associated with AD.
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| Keywords: Alzheimer’s disease, Aluminum chloride, p-Coumaric acid, Non-cognitive disturbances, Oxidative stress, Inflammation |
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Full-Text [PDF 381 kb]
(50 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/10 | Accepted: 2023/08/23 | Published: 2023/08/23
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