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Determining the pharmaceutical compounds in the Ziziphora spp. flowers extracted with methanol and Dichloromethane using GC-Mass analysis
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Asma Hatami   , Majid M.M. Sadeghi |
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Abstract: (289 Views) |
Introduction: Medicinal plants produce secondary metabolites such as phenolics, alkaloids, saponins, terpenes, and lipids. These metabolites are used as sources of drugs, cosmetics, and health products. Among these plants, Ziziphora is a genus of the Lamiaceae family with aromatic leaves. In traditional medicine, it is used for heart disorders, colds, depression, diarrhea, and cough. This study aims to investigate the phytocompounds in the methanol and dichloromethane extracts of Ziziphora spp flowers.
Methods and Materials: The aerial parts of the Ziziphora spp. were collected from the mountains of Jebalbarez, Jiroft, Kerman province, Iran, in early spring. After authenticating by the Herbarium of the Shahid Bahonar University of Kerman (Voucher no: NO4164-MIR), the Soxhlet extraction process was done to extract compounds from the flowers using methanol and dichloromethane. Gas Chromatography/Mass Spectrometry (GC/MS) was then performed to study the extracts’ phytocompounds.
Results: Both extracts were rich in compounds with pharmaceutical properties. However, the percentage of each compound was different. Of these, 5-methyl- 2-(1-methylethylidele)-Cyclohexanone (C11H18O2) made up 52% of the methanolic extract and 16.5% of the dichloromethane extract. Pentylthiophene (18%), Hexacosane (3%), 3-methylhenicosane (4.5%), 3-methylhentriacontane (3%), and Gamma-sitosterol (3%) were other dominant compounds of the dichloromethane extract. Also, Cyclohexene, 5-methyl-3- (1-methyl phenyl)-, trans (22.1%), MDMA methylene homolog (3.4%), 3-Nonen-1-yne, (Z)- (3.2%), and 3,5-Nonadien-7-yn-2-ol, (E, E)- (2.6%) were other dominant compounds of the methanolic extract.
Conclusion: In the present study, we studied the phytocompounds extracted from the Ziziphora spp flowers with two solvents, dichloromethane and methanol. Even though both extracts were rich in compounds with bioactive properties that can be applied in the pharmaceutical industry, it was revealed that the extracted compounds and their percentage differed based on the solvent.
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| Keywords: Ziziphora, Phytocompounds, Pharmaceutical properties, Medicinal plants |
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Full-Text [PDF 317 kb]
(33 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/10 | Accepted: 2023/08/23 | Published: 2023/08/23
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