Introduction: Covid-19 is one of the biggest and perhaps the most complex global challenges in the last decade. This disease first spread in China and then all over the world and quickly became a global pandemic. In the management of this disease, herbal medicines can help as a complementary treatment method. Nigella Sativa is a treatment for some diseases such as viral infections, so the purpose of this study is to investigate the effect of Nigella Sativa on the treatment of patients with covid-19. Search Method: This study is a review with keywords such as herbal medicine, Covid-19 and Nigella Sativa in several different databases including PubMed, Magiran, SID, Scopus, Science Direct, and Google Scholar search engine, from 2019 to 2023. After reviewing 11 articles and removing 3 duplicate articles, 8 titles were extracted and classified according to the subject. At the same time, the articles that were not in line with the purpose of the article, such as cultivation methods and maintenance methods of this plant, were excluded from the study. Results: Nigella sativa has antiviral, antioxidant, anti-inflammatory, anticoagulant, immune system modulator, bronchodilator, antihistaminic, antitussive, antipyretic, and analgesic activities; it is a potential herbal candidate. It is for the treatment of patients with covid-19. The thymoquinone present in the black seed plant can attach to the spike protein of the Covid-19 virus and prevent the virus from causing a lung infection. It also controls the body's immune system by preventing the release of pro-inflammatory chemicals such as interleukins. Conclusion: According to the results obtained in this study, the need to conduct more comprehensive research due to the availability of raw materials and their lower cost compared to chemical drugs should be given more attention.