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Molecular-Level Stimulations of Sodium Arsenite into Skin Aging Model of the Rat
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Fatemeh Shaki   , Mohammad Seyedabadi , Fereshte H Talebpour Amiri , Maloos Naderi , Danial Jahani , Sholeh Akbari |
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Abstract: (289 Views) |
Introduction: Skin aging is an irreversible biological process influenced by intrinsic and extrinsic factors. Environmental trace elements such as arsenic may accelerate cellular senescence. However, to our knowledge, arsenic's effects on accelerating cellular senescence have not been reported. Therefore, the present study aimed at the accelerating role of sodium arsenite (NaAs3+) on D- galactose-induced skin aging in male rats.
Methods and Materials: The rats were divided into nine groups. Naturally, aged 24-month-old group and the young control group received a standard regular diet. Other groups received varying diets, including NaAs3+, D-galactose, and NaAs3+ plus D-galactose. After eight weeks of treatment, pathological examinations, oxidative stress, mitochondrial function, hydroxyproline content, and gene expression of MMP-1, inflammatory factors (TNF-α, IL-6, and NF-kB), apoptosis-related genes (Bcl-2 and Bax), and C-Jun N-terminal kinase )JNK( were evaluated in skin tissue.
Results: NaAs3+ induced significant changes in considered factors. Co-treatment of NaAs3+ with D-gal, pathological alterations were more obvious. Moreover, NaAs3+ plus D-gal increased the level of oxidant markers and decreased antioxidant levels and hydroxyproline content. Likewise, in the D-gal+NaAs3+ group, it aggravated mitochondrial dysfunction. Accordingly, NaAs3+ co-treat with D-gal more severely increased expression of MMP-1, IL-6, TNF-α, and NF-kB, JNK, and Bax/Bcl2 expression ratio.
Conclusion: The study infers that sodium arsenite accelerates the D-galactose-induced aging process in skin tissue.
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| Keywords: D-galactose, Aging, Sodium arsenite, Hydroxyproline, Oxidative stress |
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Full-Text [PDF 326 kb]
(40 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/5 | Accepted: 2023/08/23 | Published: 2023/08/23
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