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Vitamin C administration precludes memory impairment induced by unpredictable chronic mild stress through re-establishment of the brain oxidant/antioxidant balance
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Nastaran Roshd rashidi   , Masoumeh Gholami , Nahid Khodayari |
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Abstract: (288 Views) |
Introduction: In this research aimed to investigate the effects of vitamin C (Vit C) administration on memory function and levels of oxidative stress (OS) in the hippocampal region of the brain in a rat model of unpredictable chronic mild stress (UCMS).
Methods and Materials: Vit C was intraperitoneally administered at doses of 50, 100, and 400 mg/kg at a certain time before the initiation of a stressor that was applied for four weeks. Memory function was evaluated through the Morris Water Maze (MWM) and Passive Avoidance (PA) tests. Biochemical markers were measured to reveal the status of oxidative stress and antioxidant defense system.
Results: The results found that the UCMS group had a shorter latency to enter the dark chamber (P<0.01 and P<0.05, PA test) and spent less time in the target quadrant (P<0.0001, MWM test) compared to the control group. However, they took longer to discover the platform (P<0.05 and P<0.001, MWM test). The UCMS group also had lower levels of thiol (P<0.0001), catalase (P<0.0001), and superoxide dismutase (P<0.0001), while the concentration of malondialdehyde (P<0.01) was higher in the hippocampal region of the brain compared to the control group. Interestingly, the effects of UCMS were reversed by the treatment of Vitamin C.
Conclusion: Our findings indicated that Vit C administration improves UCMS-induced impairment of learning and memory through the modulation of brain OS.
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| Keywords: Vitamin C, UCMS, Oxidative stress |
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Full-Text [PDF 263 kb]
(49 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/4 | Accepted: 2023/08/23 | Published: 2023/08/23
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