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Investigating the effect of Dimethyl itaconate following induction of hypoxia model on motor coordination, cognition and anxiety-like bahavior in Wistar male rats
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Shadi Nazarizadeh   , Zohreh Ghotbeddin , Samireh Ghafouri , Alireza Sarkaki |
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Abstract: (283 Views) |
Introduction: Epilepsy is a common neurological disorder, one of the most common forms of which is hypoxia-induced neonatal seizures (HINS). Occurrence of HINS can increase the susceptibility to epilepsy in adulthood as well as throughout life, which is associated with learning disorders and cognitive defects. The aim of the present study was to investigate the effect of dimethyl itaconate (DMI) on cognition, motor coordination, anxiety-like behavior of male rats affected by HINS.
Methods and Materials: In this study, 42 male Wistar newborn rats were used, which were randomly divided into 6 groups (n=7), including 1) control group: they received only DMI solvent without applying hypoxia. 2 and 3) groups receiving DMI with a dose of 20 and 50 mg/kg without hypoxia 4) hypoxia group: they were received DMI solvent and placed in a hypoxia chamber with 7% oxygen and 93% nitrogen concentration for 15 minutes. 5 and 6) groups receiving DMI with doses of 20 and 50 mg/kg and hypoxia. We used new object recognition tests to measure memory, rotarod and parallel bar tests for motor coordination, and Elevated Plus Maze and open field to evaluate anxiety-like behaviors.
Results: The data showed that the administration of DMI improved motor symptoms, anxiety-like behaviors, and cognition in rats with seizures induced by neonatal hypoxia (p<0.05).
Conclusion: It seems that increased oxidative stress and inflammation can be effective in the occurrence of behavioral disorders observed from hypoxia-induced convulsions in infancy, and DMI improved these behavioral disorders by reducing oxidative stress and inflammation.
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| Keywords: seizure, dimethyl itaconate, cognitive function, anxiety behavior, rat |
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Full-Text [PDF 351 kb]
(43 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/3 | Accepted: 2023/08/23 | Published: 2023/08/23
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