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Anti-inflammatory effects of selenomethionine in experimental model of temporal lobe epilepsy in male rats
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Mahsa Tashakori-Miyanroudi   , Tourandokht Baluchnejadmojarad , Mehrdad Roghani |
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Abstract: (279 Views) |
Introduction: Temporal epilepsy due to structural and metabolic changes in the hippocampus region includes degeneration of neurons. Selenomethionine has various biological activities, including strengthening the body's immune system, improving antioxidant function, and reducing oxidative stress. The aim of this study was to determine the beneficial effect of selenomethionine in preventing the inflammatory factors TNFα and TLR4 in the hippocampus region in an experimental model of temporal lobe epilepsy.
Methods and Materials: In this study, 40 male rats were divided into 4 groups: a sham, convulsive, positive control group receiving valproic acid and a group receiving selenomethionine. To induce epilepsy in animals, 2 µg of kainic acid was injected into the hippocampus for each mouse. Also, selenomethionine with a concentration of 0/1 mg/kg of body weight was given to rats by gavage from three days before the injection of kainic acid to one week after the injection of kainic acid.
Results: Induction of epilepsy with kainic acid was associated with a distinct seizure behavior and pretreatment with selenomethionine significantly reduced the severity of seizure attacks. The results of this study showed that in the convulsive group, the concentration of TNFα and TLR4 increased significantly compared to the sham group. Also, in the group receiving valproic acid and selenomethionine, compared to the kainate group, it causes a clear and significant decrease in TNFα. Although the amount of 4TLR was decreased in the groups receiving selenomethionine and valproic acid, it was not significant.
Conclusion: The administration of selenomethionine has an anti-epileptic effect, so there is a possibility that selenomethionine prevents the development of inflammation through the TNFα pathway. Therefore, in the future, by conducting additional tests, it may be possible to use this substance as one of the treatment options in the prevention of epilepsy.
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| Keywords: Temporal lobe epilepsy, Seizures, Inflammatory factors |
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Full-Text [PDF 319 kb]
(38 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/12/29 | Accepted: 2023/08/23 | Published: 2023/08/23
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