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Evaluation of alcoholic extract of Feijoa fruit in full-thickness diabetic wound healing in rats
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Reza Ataee Disfani   , Amir Reza Raoofi , Davood Nasiry |
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Abstract: (277 Views) |
Introduction: One of the most common complications of diabetes is the disorder in healing diabetic wounds. Feijoa Fruit has anti-inflammatory and antioxidant effects in repairing acute skin wounds. The present study was performed to investigate the effect of alcoholic extract of Feijoa Fruit on wound healing in diabetic male rats.
Methods and Materials: This experimental study was carried out in 45 male rats. Thirty rats were randomly divided into two groups (n=15), 30 days after induction of diabetes, and the rest were considered non-diabetic. The groups included normal wounds, diabetic wounds, and diabetic wound groups treated with 5% Feijoa Fruit extract. Sampling was performed on days 7, 14, and 21 after wounding. Assessments included wound closure rate, histological (collagen density) and stereological (tissue volume and number of cells) examinations, expression of genes involved in repair, regeneration, and angiogenesis (TGF-β, bFGF, VEGF), and inflammatory genes (TNF-α and IL-1β) using qRT-PCR.
Results: Wound closure rate, new epidermis and dermis volume, total fibroblast cells, and collagen deposition significantly increased in the treated group compared with the diabetic control group. The gene expression was significantly higher in the treatment group than in the diabetic control group. Findings showed a significant decrease in the expression of inflammatory genes and the number of mast cells in the treatment group compared with the diabetic control group.
Conclusion: The 5% extract of Feijoa Fruit, with anti-inflammatory and antioxidant effects, showed greater effects on the healing process of diabetic and chronic wounds.
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| Keywords: Diabetes mellitus, Acute wound, Wound healing, Feijoa |
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Full-Text [PDF 325 kb]
(40 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/12/16 | Accepted: 2023/08/23 | Published: 2023/08/23
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