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A systematic review of hepatotoxicity and renal toxicity models in laboratory animals
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Abbasali Abbasnezhad   , Reza Mohebbati |
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Abstract: (251 Views) |
Introduction: Therapeutic Interventions are commonly performed on laboratory animals to investigate the possible mechanism(s) of action of toxic agents as well as drugs or substances under consideration. The use of toxins in laboratory animal models, including rats, is intended to cause toxicity. This study was conducted to investigate models of liver and kidney toxicity in laboratory animals to help researchers in advancing their research goals.
Search Method: Keywords were searched from databases such as Medline, Web of Science, Scopus, and Embase up to the date of June 2021. Models of renal and hepatotoxicity caused by some toxic agents such as cisplatin, acetaminophen, doxorubicin, some anticancer drugs, and other substances were investigated through different signaling pathways.
Results: In this review article, we tried to provide a list of toxic materials and drugs that cause hepato- and/ or renal toxicity models in laboratory animals, along with relative protocols for creating those models for researchers so that they can make appropriate choices depending on the situation.
Conclusions: For the initial evaluation of the effect of each of the above substances, considering that experiments must first be performed on laboratory animals that have liver or kidney toxicity, to achieve this goal, it is important to understand the models of induction of kidney or liver toxicity in laboratory animals.
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| Keywords: Animal, Drug toxicity, Liver dysfunction, Renal injury |
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Full-Text [PDF 248 kb]
(44 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/12/15 | Accepted: 2023/08/23 | Published: 2023/08/23
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