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Hepato-renal protective potential of dimethyl fumarate in alloxan-induced diabetic mice model
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Ramin Ataee   , Parisa Saberi-Hasanabadi , Fatemeh Shaki , Mohammad Karami |
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Abstract: (281 Views) |
Introduction: The growing epidemic of diabetes is one of the most common causes of chronic kidney disease and liver failure. Despite advances in diabetes-related treatments, the effects of the disease have not yet been adequately reversed or prevented in patients.
Methods and Materials: In this study, forty male mice were divided into eight groups with five animals in each. Type 1 diabetes mice models were established using multiple low-dose alloxan, and the diabetic mice were treated with three doses of dimethyl fumarate (DMF) i.e. low, medium, and high viz. 20, 40, and 80 mg/kg, respectively for a period of 21 days. Then, specific tests were done to evaluate blood biochemical parameters, oxidative stress markers, and histopathological changes in the treated mice's kidneys and liver.
Results: The obtained results showed remarkably improved anti-diabetic, hepatorenal-protective, and oxidative stress indexes of DMF in alloxan-induced diabetic mice (p< 0.001). Treated diabetic mice with DMF demonstrated a noteworthy decrease in blood glucose levels when compared with alloxan-treated mice (p< 0.001). Diabetic liver and kidney tissues showed marked dilation of bile ducts, tubules, infiltration, and inflammation. On the contrary, the histological features of the treated mice with DMF improve as shown by the normal size of glomerular capillaries along with a decrease in less dilatation of ducts in comparison with alloxan-induced mice.
Conclusions: Collectively, it can be concluded that the role of DMF as a blood sugar reducer and improvement of diabetes complications is very significant, likely via improvement of oxidative stress indicators and tissue characteristics of the kidney and liver.
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| Keywords: Diabetes, Dimethyl fumarate, Alloxan, Hepato-renal protective effects |
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Full-Text [PDF 375 kb]
(47 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/12/4 | Accepted: 2023/08/23 | Published: 2023/08/23
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