|
Lavandula angustifolia aqueous extract ameliorates anxiety and depressive-like behaviors in chronic mild stress-treated male rats
|
Mir Behrad Aghazadeh Ghadim   , Fatemeh Kheirollahzadeh , Mohsen Sisakht , Zahra Khoshdel |
|
|
|
Abstract: (283 Views) |
Introduction: Depression is a widespread mental illness that is rapidly increasing globally. The study aims to show the possible anxiolytic and antidepressant-like properties of an oral lavender’s flower aqueous extract (LAE) in chronic mild stress (CMS) model of rats.
Methods and Materials: Test and control rats received LAE (200 or 400 mg/ kg) and distilled water respectively, Tests of Sucrose preference (SP), elevated plus maze (EPM), and open field (OFT) were used to evaluate rats’ behavioral changes. Real-time PCR, Western blot, biochemical analysis, Enzymes ALT, AST, as well as BUN and creatinine, were examined in the blood samples to assess the gene expression and the potential toxicity of LAE.
Results: The percentage of SP in the CMS group was 2.6 times less than that of the unstressed group (p<0.05). However, administration of LAE (200 and 400 mg/kg) increased the SP of CMS rats by 2.0 and 3.01 times respectively in comparison to those of the stressed animals. EPM analysis revealed that 5-week CMS exposure significantly reduced the number of entries in open arms (0.8 times) as compared to unstressed rats (6.6 times). LAE (200 and 400 mg/kg) reversed CMS by increasing both the total time spent (1.73 and 1.23% respectively) and the number of entries in the open arms (5 and 5.7 times respectively) compared to those related to the unstressed group (p<0.05).
Conclusion: CMS decreased the number of entries and time spent in the central zone of OFT. Administration of LAE (200 and 400 mg/ kg) to stressed rats enhanced the total distance traveled by 3.30 and 2.65% to the control rats. Taken together, oral lavender aqueous extracts showed ameliorating effects on depression and anxiety-related behaviors in rats.
|
|
| Keywords: Depression, lavender, chronic mild stress, anxiety, aqueous extract |
|
|
Full-Text [PDF 344 kb]
(52 Downloads)
|
Type of Study: Research |
Subject:
General
Received: 2023/11/25 | Accepted: 2023/08/23 | Published: 2023/08/23
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
