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The Effect of Propofol and Ketamine (ketofol) Combination in Induction of Anesthesia
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Hedieh Firouzian   , Elnaz Doostmohammadi , Mehdi Firoozi |
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Abstract: (282 Views) |
Introduction: Ketamine has sedative, analgesic, and anesthetic properties, and one of its most important advantages is the absence of respiratory depression. Therefore, it is an ideal drug for various types of procedures. Propofol is also one of the most common drugs used for inducing anesthesia, which leads to a significant decrease in arterial blood pressureEnsuring hemodynamic stability, providing analgesia, and administering sedation are crucial aspects of anesthesia. The purpose of this study is to investigate the effect of propofol and ketamine (“Ketofol”) combination in the induction of anesthesia.
Methods and Materials: The present review study is the result of a search through journal database platforms such as Google Scholar, Pubmed, and ScienceDirect as search engines for journals related to this article between 2018 and 2023 with the keywords propofol and ketamine, ketofol, analgesia, and hemodynamic changes.32 studies related to the topic were examined, and after removing duplicates,21 articles were used in this study.
Results: Adding ketamine to propofol (“ketofol”) prolongs the sedation time compared to propofol and has a significant role in reducing pain. Infusion of hypnotic doses of ketofol resulted in increased diastolic and systolic blood pressure, and further induction improved blood pressure stability compared to propofol infusion. The combination of propofol and ketamine reduces the hemodynamic changes caused by the injection of ketamine. Additionally, it plays a part in minimizing the required dosage of propofol and provides enhanced analgesia.
Conclusion: According to the obtained results, it has been found that the mixture of propofol and ketamine can contribute to maintaining a stable hemodynamic state and providing analgesia. This combination can prove to be a valuable option for sedation and general anesthesia in a range of medical situations.
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| Keywords: Ketofol, analgesia, sedation, hemodynamic changes |
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Full-Text [PDF 372 kb]
(46 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/11/24 | Accepted: 2023/08/23 | Published: 2023/08/23
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