Introduction: Diabetes mellitus, the most common metabolic disorder, is a result of insulin insufficiency or dysfunction. The best methods for managing diabetes are diet and exercise, or diet combined with insulin or hypoglycemic medications. It should be noted that drugs used in diabetes such as metformin and insulin have side effects. Therefore, herbal treatments have been recommended as viable substitutes for antidiabetic medications since they have fewer negative effects. Several pharmacological pathways are used by herbs like acacia to lower blood sugar levels. The purpose of this study is to investigate the effect of acacia on diabetes. Materials and Method: This review is conducted by searching the keywords of acacia, Acacia arabica, Samghe arabi, and diabetes mellitus through journal database platforms such as Google Scholar, Pubmed, and ScienceDirect as search engines for journals related to this article between 1998 and 2023. 57 articles were studied, and after removing the articles that were not consistent with the purpose of this study and removing the duplicates, a total of 30 articles were included. Result: Studies have shown that acacia seeds contain a substance that can lower blood sugar levels in normoglycemic individuals, indicating that the action involves the release of insulin from pancreatic beta-cells. Furthermore, in an animal model of type 2 diabetes, polyphenols from the bark of Acacia showed hypoglycemic activity, reduced body weight, and improved insulin sensitivity, indicating their beneficial effects on DM. Conclusion: According to the results obtained in this study, due to the availability of raw materials and the lower cost of these plants compared to chemical drugs, more comprehensive research should be considered.